Hypertension Drugs: Alzheimer’s Perk?

Hypertension Drugs: Alzheimer’s Perk?

Oct. 26, 2007 — Certain hypertension (high blood weight) drugs may counter Alzheimer’s disease.

That news comes from lab tests on mice, not people.

The analysts who conducted those tests aren’t prepared to prescribe blood pressure drugs for Alzheimer’s anticipation, but they see great reason to test the plausibility.

“The utilize of these drugs for their potential anti-Alzheimer’s malady role is still exceedingly experimental,” says Giulio Maria Pasinetti, MD, PhD, in a news release.

Pasinetti — who works at New York’s Mount Sinai School of Medicine — had examined previous ponders linking high blood weight drugs to diminished hazard of Alzheimer’s illness.

Those ponders were based on patients’ therapeutic records, not direct tests of the drugs. So Pasinetti’s group headed to their lab to do a few tests.

Alzheimer’s Explore

Pasinetti and colleagues pitted 55 hypertension drugs against beta-amyloid proteins in test tubes.

Beta-amyloid proteins shape plaque found in brains ravaged by Alzheimer’s illness.

Seven drugs thwarted the buildup of beta-amyloid proteins.

Those drugs, which come from various classes of hypertension drugs, are:

Propranolol hydrochloride (sold nonexclusively and as Inderal) Carvedilol (sold generically and as Coreg) Valsartan (sold as Diovan) Losartan (sold as Cozaar) Nicardipine hydrochloride (sold generically and as Cardene) Amiloride hydrochloride (sold blandly and as Midamor) Hydralazine hydrochloride (sold blandly and as Apresoline)

Encourage lab tests showed that one of those seven drugs, Diovan, hindered certain beta-amyloid fixings.

Diovan Tried in Mice

The researchers at that point tried Diovan in mice that were hereditarily at chance for Alzheimer’s disease.

Some of the mice drank water bound with Diovan. Their Diovan dose was lower than that used for people with tall blood pressure.

For comparison, other mice got conventional water without Diovan.

After drinking their assigned water for 11 months, the mice took a memory test in which they had to memorize and keep in mind the way through a watery maze.

The mice that drank the Diovan water fared best within the maze test.

But when the analysts tested mice without the dementia quality glitch, Diovan treatment didn’t help or harmed the mice navigate the watery maze.

There is no prove that Diovan prevents or slows dementia in individuals, but the discoveries in mice may rouse such a ponder in individuals at tall risk for Alzheimer’s, Pasinetti’s group proposes.

Their think about shows up in the Journal of Clinical Investigation.

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