Thalidomide for Lou Gehrig’s Disease?

Thalidomide for Lou Gehrig’s Disease?

March 16, 2006 — Tests on lab mice appear that the drugs thalidomide and lenalidomide may offer assistance control amyotrophic sidelong sclerosis (ALS), widely called “Lou Gehrig’s malady.”

ALS is a progressive degenerative neurological clutter that has no cure. For reasons that aren’t understood, the nerve cells of the brain and spinal rope that control voluntary muscle development continuously deteriorate. As a result, muscles squander away, leading to loss of motion and passing, as a rule in two to five a long time.

ALS is frequently nicknamed “Lou Gehrig’s infection” after the baseball player who kicked the bucket of ALS in 1941.

Thalidomide and lenalidomide showed promise in mice with ALS, the analysts report. In any case, they stretch that they don’t know however on the off chance that the same would be genuine for people.

The study shows up within the Journal of Neuroscience.

Around the Consider

The analysts included Mahmoud Kiaei, PhD, of Cornell University’s Weill Therapeutic College.

Kiaei and colleagues didn’t test the drugs on any people. But they did study samples of spinal rope tissue from 12 perished individuals, half of whom had had ALS.

The tissue tests appeared tall levels of two incendiary proteins. Those proteins — called tumor rot calculate alpha (TNF-alpha) and fibroblast-associated cell-surface ligand (FasL) — both turned up in tall levels in untreated mice with ALS.

The researchers part the mice into three groups. One bunch of mice got thalidomide, another bunch got lenalidomide, and the third bunch got infusions of salt water, which has no restorative utilize in ALS.

Study’s Comes about

The researchers tried thalidomide and lenalidomide on the mice to see in the event that those drugs would block the inflammatory proteins TNF-alpha and FasL.

The drugs appeared to have that impact. Levels of TNF-alpha and FasL fell within the mice treated with thalidomide and lenalidomide. Survival too improved and ALS worsened more gradually within the drug-treated mice.

Be that as it may, much work lies ahead to see on the off chance that the same is true for individuals.

“Sedate digestion system and other factors are just so distinctive between mice and humans,” Kiaei says in a Cornell news release. “So distant, none of what’s worked for ALS in creature models has interpreted to effective medications.”

“Still, right presently we have so little to offer patients in this annihilating illness,” Kiaei includes. “This does offer unused hope.”

Following Steps

Kiaei says the next step is “to test and see whether these drugs work in mice in case we regulate them at the time of infection onset. That’s much more important for patients since that’s when they would first be endorsed drugs to battle ALS.”

Thalidomide is known to cause severe birth defects. It is currently affirmed by the FDA — with strict rules to assist prevent birth defects — to treat weakening and deforming skin bruises associated with erythema nodosum leprosum, an incendiary complication of sickness.

“Since pregnancy is not an issue for women with ALS, the concern with birth defects should not slow this inquire about or thalidomide’s potential utilize in patients,” Kiaei says. “Still, we ought to always make beyond any doubt thalidomide is utilized beneath strict conditions, should clinical trials begin.”

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